After vaccination for hepatitis B, which serology will be positive?

Following vaccination for hepatitis B, the presence of HBsAb (hepatitis B surface antibody) in serology is the expected outcome that indicates a successful immune response to the vaccine. Vaccination stimulates the immune system to produce antibodies specifically against the hepatitis B surface antigen (HBsAg), which helps to provide protective immunity against future hepatitis B virus infections.

Once the vaccine is administered, individuals will typically show an increase in HBsAb levels, demonstrating that the immune system recognizes the vaccine and is prepared to respond to the actual virus if exposure occurs. The presence of HBsAg and HBcAb is not expected post-vaccination. HBsAg would indicate an active infection with the virus, while HBcAb reflects past exposure to the virus, neither of which occurs purely due to vaccination. Therefore, the presence of HBsAb is a clear indicator of vaccine-induced immunity.