At what point in pregnancy is RhoGAM typically administered?

RhoGAM is typically administered at 28 weeks of gestation to Rh-negative pregnant women who are carrying an Rh-positive fetus. This timing is crucial because it serves as a preventive measure against Rh incompatibility, which can lead to hemolytic disease of the newborn. The administration at this point in the pregnancy allows for the clearance of any Rh-positive fetal red blood cells that may have entered the maternal circulation during the later part of the pregnancy, thereby reducing the risk of sensitization.

RhoGAM can also be given right after delivery if the newborn is found to be Rh-positive, but the standard prophylactic administration at 28 weeks ensures that the mother is protected before potential exposure during delivery or any other event that might result in fetal and maternal blood mixing. By giving RhoGAM at 28 weeks, healthcare providers can help prevent the production of maternal antibodies against Rh-positive blood cells, which is vital for the health of future pregnancies.