In cases of Stevens-Johnson syndrome when epidermal detachment exceeds 30%, what condition is referred to?

In cases of Stevens-Johnson syndrome (SJS), the condition can escalate to Toxic Epidermal Necrolysis (TEN) when epidermal detachment exceeds 30%. TEN is a severe and life-threatening condition characterized by widespread skin detachment and mucosal erosion, often resulting from adverse drug reactions. The defining criterion distinguishing TEN from SJS is the extent of skin loss; TEN involves a greater percentage of the body surface area.

SJS and TEN are considered part of a spectrum, with SJS typically presenting with less than 10% body surface involvement. As the percentage of epidermal detachment increases, particularly past the 30% threshold, the severity and potential morbidity associated with the condition also significantly increase, transitioning from SJS to TEN. Understanding this continuum is critical in clinical practice, as it influences management strategies and the urgency of intervention.