What factor of maternal serum alpha-feto-protein level might indicate a possible abnormality?

High levels of maternal serum alpha-feto-protein (AFP) can indicate potential abnormalities during pregnancy. This protein is produced by the fetal liver, and its levels can be measured in the mother's blood during the second trimester. Elevated levels of AFP can be associated with several conditions, including neural tube defects (such as spina bifida) and abdominal wall defects (like omphalocele). Additionally, high AFP levels may signal multiple gestations or certain fetal conditions that require further investigation.

It is important to note that while elevated levels can signal these issues, they should be interpreted in conjunction with other diagnostic tests and clinical findings, as not all cases of high AFP will indicate a serious problem, and some elevated levels can be seen in normal pregnancies as well. The identification of these high levels prompts caregivers to consider further diagnostic imaging or assessments to determine the health and development of the fetus.