What hormonal condition is associated with McCune-Albright syndrome?

McCune-Albright syndrome is a complex genetic disorder caused by a mutation in the GNAS gene, leading to various endocrine dysfunctions. In this condition, multiple hormonal abnormalities can occur due to the dysregulation of endocrine glands.

One of the hallmark features of McCune-Albright syndrome is endocrine hyperfunction, where certain glands may produce hormones at levels that exceed normal physiological ranges. This hyperfunction can manifest in various ways, affecting multiple organ systems in the body.

Precocious puberty is another significant manifestation associated with this syndrome. The activation of ovarian or testicular function at an unusually early age characterizes this condition, which can lead to early sexual maturation in boys and girls.

Additionally, ACTH-independent Cushing syndrome can develop in patients with McCune-Albright syndrome. This occurs due to autonomous adrenal hormone production, particularly cortisol, independent of adrenocorticotropic hormone (ACTH) regulation.

Given that McCune-Albright syndrome can lead to all these hormonal conditions — endocrine hyperfunction, precocious puberty, and ACTH-independent Cushing syndrome — the most comprehensive answer reflects the syndrome's multifaceted nature concerning hormonal abnormalities.