What is a key feature of Stevens-Johnson syndrome?

Stevens-Johnson syndrome (SJS) is a severe and potentially life-threatening condition characterized primarily by widespread blisters and painful lesions on the skin and mucous membranes. This acute reaction typically follows a viral infection or is triggered by medications. The presence of widespread blisters, which can cover large areas of the body, is a hallmark of this syndrome, signifying significant epidermal detachment and inflammation.

In the context of the other options, while localized skin peeling, intensely itchy lesions, and persistent fever may accompany various skin disorders or reactions, they do not encapsulate the defining features of SJS. Instead, it is the widespread blisters that signify the severity of this condition and often lead to complications such as infection, fluid loss, and scarring. Thus, recognizing the blistering aspect of SJS is crucial for timely diagnosis and management.