What is a significant adverse effect of isotretinoin therapy?

Isotretinoin is a retinoid commonly used to treat severe acne, particularly when other treatments have failed. One of the most significant adverse effects associated with isotretinoin therapy is its teratogenic effects. This means that if isotretinoin is taken during pregnancy, it can cause severe birth defects in the developing fetus. The teratogenic potential is so high that it is necessary for women of childbearing age to adhere to strict guidelines, including the use of effective contraception before, during, and after treatment.

The importance of monitoring for these effects is underscored by programs like the iPLEDGE program in the United States, which is designed to prevent fetal exposure to isotretinoin. While isotretinoin can lead to various side effects, such as dry skin or mucous membranes, the risk of teratogenic effects remains a crucial consideration for clinicians and patients when discussing the risk-benefit ratio of this medication.