What is the characteristic feature of the lesions associated with Erythema multiforme?

The characteristic feature of the lesions associated with Erythema multiforme is that they are symmetric vesiculobullous lesions. Erythema multiforme typically presents with target lesions or "targetoid" lesions, which are often raised and feature a central blister or vesicle. These lesions appear symmetrically on the extremities and mucous membranes, and they can vary in size. The vesiculobullous nature of the lesions is key in differentiating Erythema multiforme from other dermatological conditions, where the configuration and morphology of the lesions play significant roles in diagnosis. Understanding these features helps in identifying Erythema multiforme and appropriately managing the condition.

The other options present characteristics that do not align with the typical presentation of Erythema multiforme lesions. For instance, itchy and crusted lesions are more suggestive of other dermatological issues like infections or eczema, while non-painful flat lesions do not match the vesicular and bullous nature seen in Erythema multiforme. In addition, a burning sensation without itchiness may be present in some skin conditions but is not a defining feature of the lesions in Erythema multiforme, which