What is the initial treatment for mild cases of von Willebrand's disease?

The initial treatment for mild cases of von Willebrand's disease is desmopressin. This medication works by stimulating the release of von Willebrand factor (vWF) and factor VIII from the endothelial cells, which are crucial for proper blood clotting. In patients with von Willebrand’s disease, there is typically a deficiency or dysfunction of vWF, leading to impaired platelet adhesion and increased bleeding risk. Desmopressin effectively enhances the levels of vWF, thereby improving clotting function.

This approach is particularly effective in mild cases because it is a non-invasive option that can be administered intranasally or intravenously, allowing patients to manage their condition effectively without the need for more complex treatments, such as those required in moderate to severe cases. Other treatments, like factor VIII concentrates or cryoprecipitate, are typically reserved for more severe forms of the disease or specific bleeding episodes, making desmopressin a first-line choice for mild cases.