What is the most common symptom of primary biliary cirrhosis?

The most common symptom of primary biliary cirrhosis is pruritus, which is often one of the earliest signs experienced by patients. This intense itching occurs due to the accumulation of bile acids in the bloodstream, as the liver becomes increasingly unable to properly excrete bile. The mechanism behind this symptom is related to the cholestatic nature of the disease, where bile flow is obstructed and leads to these secondary effects.

While fatigue, jaundice, and abdominal pain are indeed symptoms associated with liver disease and can also be present in patients with primary biliary cirrhosis, pruritus stands out as the hallmark symptom that may present even before other signs become apparent. Patients often describe the itching as being worse at night, which can significantly impact their quality of life and sleep patterns. Understanding the prevalence of pruritus in this condition helps healthcare providers identify and manage the disease more effectively.