What is the typical course of IgA nephropathy?

IgA nephropathy, also known as Berger's disease, typically has a course that can vary among individuals, but it is most often characterized as having a benign progression with the potential for some individuals to experience progression to chronic kidney disease. Many patients may remain stable and not experience significant deterioration for years, which aligns with the idea that while there is potential for progression, many cases are managed without severe outcomes.

In some cases, however, they might experience episodes of hematuria or proteinuria but often do not require aggressive interventions. Thus, the characterization of IgA nephropathy as most benign captures the general outlook for a significant number of patients. While certain patients may experience more severe disease or progress towards end-stage renal disease, this is not the typical scenario for the majority.

The other choices suggest a more concerning course of the disease or immediate medical needs that do not align with the general understanding of IgA nephropathy’s typical presentation and long-term outcomes.