What laboratory finding is commonly associated with Alport Syndrome?

Alport Syndrome is a genetic disorder that affects the kidneys, eyes, and ears, primarily characterized by progressive kidney disease due to mutations in collagen genes that lead to structural and functional abnormalities in the glomerular basement membrane. One of the hallmark laboratory findings associated with this condition is glomerular hematuria, which means the presence of blood in the urine originating from the glomeruli.

This occurs because the integrity of the glomerular filtration barrier is compromised, which allows red blood cells to leak into the urine. In patients with Alport Syndrome, hematuria can be one of the earliest signs of kidney involvement, often detected before the onset of significant proteinuria or other renal symptoms.

The other choices, while they may be associated with other renal conditions, do not specifically characterize Alport Syndrome in the same way. For instance, hypercalcemia is more commonly related to issues such as hyperparathyroidism, hypoproteinemia often indicates nephrotic syndrome, and hyperuricemia could be seen in conditions related to gout or other metabolic disturbances. Therefore, glomerular hematuria stands out as the most indicative laboratory finding for Alport Syndrome.