What laboratory findings are typical for Chronic Myelogenous Leukemia (CML)?

Chronic Myelogenous Leukemia (CML) is characterized by specific laboratory findings that reflect the disease's pathology. One of the hallmark features of CML is the significant elevation of white blood cell (WBC) counts. This increase in WBCs is primarily due to the proliferation of myeloid cells, which is driven by a genetic mutation typically involving the Philadelphia chromosome.

In addition to elevated WBC counts, CML can also present with elevated platelet counts (thrombocytosis) during certain stages of the disease. This occurs as the bone marrow remains hyperactive and produces excess blood cells, including platelets, which can contribute to complications such as thrombotic events.

Thus, elevated WBCs and platelets are consistent laboratory findings in patients with CML. Therefore, the answer highlighting both elevated WBCs and platelets accurately reflects the typical hematological profile observed in this condition. Understanding these laboratory values is crucial for diagnosis, monitoring disease progression, and guiding treatment options in CML.