What medical procedure can be curative in Myasthenia Gravis for those failing medical treatment?

In cases of Myasthenia Gravis (MG) that do not respond adequately to medical treatment, thymectomy is considered a potentially curative procedure. Thymectomy involves the surgical removal of the thymus gland, which is believed to play a role in the pathophysiology of MG, particularly in patients with thymoma or hyperplasia. The thymus gland is important for immune function, and its removal can lead to improved symptoms and, in some cases, remission of the disease.

The benefit of thymectomy is particularly significant in younger patients and those with generalized Myasthenia Gravis. Studies have shown that many patients experience a reduction in symptoms or improvement in muscle strength over time following this procedure, making it a viable option for those not managing well with medication alone.

Other options such as neurostimulation therapy and electrophysiology testing do not offer curative approaches for Myasthenia Gravis; rather, they serve diagnostic or supportive roles in managing the condition. Chemotherapy, while used in some autoimmune conditions, is not a standard treatment for Myasthenia Gravis and does not curatively address the underlying issues of this specific disorder.