Which intervention is proven to prolong life in patients with COPD?

Smoking cessation is the only intervention that has been consistently proven to prolong life in patients with chronic obstructive pulmonary disease (COPD). Tobacco smoke is the primary cause of COPD, and quitting smoking can significantly slow the progression of the disease and improve overall health outcomes. Research has shown that individuals who stop smoking experience a reduction in exacerbations, better lung function, and improved quality of life, which collectively contribute to increased mortality benefits.

While the other interventions listed might improve symptoms or quality of life, they do not have strong evidence supporting their role in prolonging life. Long-term corticosteroids can manage exacerbations and inflammation but are associated with significant side effects and do not directly address the underlying cause of COPD. Inhaled anti-cholinergics can enhance airway function and relieve symptoms, but again, they do not have a definitive impact on survival. Frequent outpatient follow-ups are essential for monitoring and managing patients but do not in themselves lead to improved survival rates in COPD patients.

Thus, the evidence surrounding smoking cessation highlights its crucial role not only in managing COPD but also in significantly extending the lifespan of affected individuals.