Which medication is commonly implicated in causing fixed drug eruptions?

Fixed drug eruptions are a specific type of drug-induced skin reaction characterized by the recurrence of well-defined erythematous plaques at the same site upon re-exposure to the triggering medication. Tetracycline antibiotics are particularly known for this type of reaction. They can lead to localized skin lesions that appear when the drug is reintroduced, typically after a course of treatment or even months later.

The mechanism of fixed drug eruption is believed to involve a T-cell mediated immune response, where the skin reacts to the drug in question, leading to this distinctive pattern. Other medications may cause various dermatological reactions, but fixed drug eruptions are most commonly noted with tetracycline antibiotics among the options given.

While other classes of medications might cause different types of skin reactions, the association between tetracycline antibiotics and fixed drug eruptions is well-documented in medical literature. This distinguishes them in a significant way from the other medications listed, which are less commonly implicated in this specific condition.