Which of the following is a prominent characteristic of Myasthenia Gravis?

Myasthenia Gravis is primarily characterized by fluctuating muscle weakness that tends to worsen with repeated use of the muscles and typically becomes more pronounced throughout the day. This pattern of muscle fatigability is due to the autoimmune nature of the disease, where antibodies attack the acetylcholine receptors at the neuromuscular junction, resulting in decreased communication between nerves and muscles.

As the day progresses, the demands placed on the muscles can lead to increased fatigue, which is why individuals with Myasthenia Gravis often experience a more significant weakness later in the day compared to the morning when they may feel somewhat stronger. This distinctive worsening with activity sets Myasthenia Gravis apart from other neuromuscular disorders, making it a critical aspect to recognize in diagnosis and management.