Which symptoms are commonly associated with Chronic Myelogenous Leukemia (CML)?

Chronic Myelogenous Leukemia (CML) is a type of cancer that affects the blood and bone marrow, characterized by the overproduction of myeloid cells. The symptoms associated with CML typically arise from the effects of abnormal blood cell production and its impact on normal bodily functions.

Fatigue is one of the hallmark symptoms of CML, stemming from anemia due to the replacement of normal blood cells with the malignant cells and insufficient amounts of red blood cells. Weight loss is also frequently observed as the disease progresses, often due to the body's increased metabolic demands and a reduced appetite. Low-grade fevers can occur as a result of the body’s immune response to disease processes or due to the underlying leukemic process itself.

In contrast, the other choices list symptoms that do not align as closely with the typical presentation of CML. For instance, while weight gain, high fever, and joint pain may arise from various conditions, they are not characteristic of CML. Additionally, severe headaches, respiratory distress, and joint swelling are more indicative of other medical issues rather than CML. Severe anemia, hypertension, and dizziness, while they can relate to other blood disorders, do not reflect the specific symptomatology associated predominantly with CML.