Which viral infection is commonly associated with erythema multiforme?

Erythema multiforme is a condition characterized by the appearance of distinct target lesions on the skin, and it is indeed commonly associated with various viral infections. Among those, Herpes Simplex Virus (HSV) is the most well-documented viral trigger. The relationship between HSV and erythema multiforme is particularly significant because many cases of erythema multiforme occur following outbreaks or reactivation of HSV.

HSV can cause not only herpetic lesions but also a subsequent immune response that manifests as erythema multiforme. This condition can occur in both the context of an acute outbreak as well as after an individual has healed from viral lesions.

In contrast, while other viral infections can potentially trigger different skin reactions, they are not as strongly linked to erythema multiforme as HSV. For instance, Varicella may lead to other dermatological issues but is less frequently associated with the distinct target lesions and subsequent inflammatory response seen in erythema multiforme. HIV is associated with a range of dermatologic conditions but has a different pathophysiological link to skin manifestations. Influenza primarily affects the respiratory system without a direct association with erythema multiforme. Thus, the connection between